Atopic dermatitis: time for a tailor-made therapy

Atopic dermatitis is the most common chronic inflammatory skin disease, affecting up to 7% of adults and 25% of children.
1
  • Eichenfield LF
  • Tom WL
  • Chamlin SL
  • et al.
Care recommendations for the management of atopic dermatitis: section 1. Diagnosis and evaluation of atopic dermatitis.

J Am Acad Dermatol. 2014 ; 70: 338-351

The pathogenesis includes inflammation, skin barrier dysfunction, dysbiosis, and modulation by environmental and genetic factors. Patients typically present with erythema, xerosis, excoriations, lichenification, and pruritus. It affects the quality of life of patients and their family members, and patients with atopic dermatitis are at higher risk of allergic comorbidities.

1
  • Eichenfield LF
  • Tom WL
  • Chamlin SL
  • et al.
Care recommendations for the management of atopic dermatitis: section 1. Diagnosis and evaluation of atopic dermatitis.

J Am Acad Dermatol. 2014 ; 70: 338-351

Conventional treatment for moderate to severe atopic dermatitis is systemic immunosuppressants or corticosteroids, which can cause significant side effects. As a result, the development of well-tolerated immunomodulators has led to improved quality of life for patients.

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