Autologous fat transplant, platelet-rich plasma-like treatments for acne scars

The efficacy and safety of autologous fat transplant and platelet-rich plasma for the treatment of post-acne scars has been supported by data from studies published in the Journal of Cosmetic Dermatology. The 2 treatment modalities had similar scar improvement scores and comparable patient satisfaction rates.

This study included patients with post-acne scars who sought care at a dermatology clinic in Karnataka, India. Patients with active acne on the face were not eligible for inclusion. The patients were divided into 2 treatment groups. The first group received a single subcision session with autologous fat grafting. The second group received subcision followed by intradermal injection of platelet rich plasma (PRP) once a month for 3 months. Clinical photographs were taken before and after each treatment session. Response to treatment was assessed using the Goodman & Baron Quantitative Global Acne Scar Ranking System.

A total of 24 patients were included, including 17 women and 7 men. All patients were between 18 and 45 years old. The mean duration of acne scars was 5.24 ± 2.08 years. At baseline, 37.5% of patients had light scars according to the Goodman & Baron system, 45.8% had moderate scars and 16.7% had severe scars. All patients completed full treatment and attended a follow-up visit. Both groups showed significant reductions in acne scars. The fat graft group had an improvement in mean score of 61.23% ± 9.48% from baseline (P <.001 the intradermal prp group had a mean improvement of>P <.001 after the end of treatment percentages patients with light and moderate scars were respectively. no patient remained in severe scarring group during follow-up. at post-treatment visit described their results as a total these had received fat grafting intradermal prp. main side effects mild pain transient edema erythema procedure. symptoms disappeared within to days without treatment.>

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Both treatment modalities tested in this study resulted in significant improvements in acne scars, the researchers noted. However, the small study cohort limits generalization of the data; these treatment methods warrant further investigation in a larger framework, they wrote.


Shetty VH, Bhandary SN, Bhandary R, ​​Suvarna C. A comparative study of the efficacy and safety of autologous fat grafting versus platelet-rich plasma in the treatment of post-acne scars. J Cosmet Dermatol. Published online October 4, 2021. doi: 10.1111 / jocd.14503

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