Effectiveness of acne treatment does not appear to be affected by BMI


The following article is part of our coverage of the American Academy of Dermatology (AAD 2021) Annual Meeting which is being held virtually April 23-25, 2021. Dermatology advisorCompany staff will report on the most advanced research in dermatological advancements and clinical care. Check back for the latest news from AAD 2021.

The effectiveness of topical acne treatments was not affected by body mass index (BMI) according to study results presented at the American Academy of Dermatology’s Virtual Meeting Experience (AAD VMX) 2021, held online from April 23 to April 25, 2021.


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The researchers analyzed data from 5 phase 3 double-blind studies for this post hoc analysis. Patients with moderate to severe acne (overall elevator severity score [EGSS], 3 or 4) were randomly assigned in a 1: 1 ratio to receive once daily clindamycin / benzoyl peroxide gel 1.2% / 3.75% (C / BPO; n = 250), 0.045% tazarotene lotion (n = 798), 0.05% tretinoin lotion (n = 816) or corresponding placebo vehicle for 12 weeks. Participants were stratified into subgroups from underweight to normal (

Among all active treatment recipients, acne lesions were reduced by more than 50% at 12 weeks. Compared to matched placebo cohorts, a grade reduction of at least 2 was observed in normal and underweight EGSS participants and a score of at least “almost clear” was observed in all groups. treatment (C / BPO: 29% vs 15%; tretinoin: 22% vs 10%; tazarotene: 30% vs 16%; all P P

However, among obese participants, only tazarotene (34% vs 22%; P

The number of inflammatory lesions was significantly reduced in all patients receiving active treatment who were of normal weight or underweight (all P <.001 and overweight bpo:>P<.001 tretinoin:>P P <.001 compared to placebo. among obese participants inflammatory lesions were significantly reduced in the c bpo group squares average change vs.>P

For non-inflammatory lesions, all active treatments reduced the number of lesions at week 12 compared to placebo (all P £ 0.01) except in obese tretinoin recipients (mean change in LS, -44.9% vs. -38.5%). All reported side effects were mild to moderate.

The study authors concluded that topical acne treatments were effective in all participants, reducing the number of inflammatory and non-inflammatory lesions and with an acceptable safety profile.

Disclosure: Several authors have declared affiliations with the industry. Please refer to the original article for a full list of disclosures.

Reference

Cook-Bolden FE, Green L, Keri J et al. Impact of Body Mass Index (BMI) on the Effectiveness of Three Topical Acne Treatments in Patients with Moderate to Severe Acne. Presented at: American Academy of Dermatology (AAD VMX) Virtual Meeting Experience 2021; April 23-25, 2021. Summary / Poster 27615.


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